BULLETIN FOR THE HISTORY OF CHEMISTRY
Volume 50, 2025
Hanuš, Lumír Ondřej, “The Whole History of the Isolation of Anandamide,”Bull. Hist. Chem., 2025, 50, 57-64.
https://doi.org/10.70359/bhc2025v050p057
Abstract/Description: The discovery of cannabinoid receptors in human beings led Raphael Mechoulam to realize that the receptors were present in the body not for cannabis-derived compounds but rather for naturally occurring endogenous substances. This paper is a firsthand account of the research that led to the discovery of the first endogenous ligand for these receptors—the discovery of anandamide.